Solution-Phase Methods¶
Protocols for solution-phase transformations commonly used in cyclic peptide synthesis, including macrolactamization, amide coupling, and classical organic reactions.
Protocols¶
- Cyclization —Low-concentration macrolactamization for head-to-tail cyclic peptides.
- Amide Coupling with DSC —Disuccinimidyl carbonate-mediated amide bond formation.
- Schotten-Baumann Reaction —Classical acylation reaction for installing carbamate protecting groups.